Limba
Romanian
Romanian
English|
Ailanthone (AIL, Δ13-Dehydrochaparrinone), a natural anti-hepatocellular carcinoma (HCC) component in Ailanthus altissima, induces G0/G1-phase cell cycle arrest by decreasing expression of cyclinsand CDKsand increases expression of p21and p27. Ailanthone triggers DNA damagecharacterized by activation of the ATM/ATRpathway. Ailanthone induces apoptosiswhich is mitochondrion-mediated and involves the PI3K/AKTsignaling pathway in Huh7 cells. Ailanthone is also a potent inhibitor of both full-length Androgen Receptor(AR-FL) and constitutively active truncated AR splice variants (AR-Vs, AR1-651) with IC50 of 69 nM and 309 nM, respectively.
| Price | 1.597,00 RON (preturile sunt fara TVA) |
|---|---|
| Description |
Ailanthone (AIL, Δ13-Dehydrochaparrinone), a natural anti-hepatocellular carcinoma (HCC) component in Ailanthus altissima, induces G0/G1-phase cell cycle arrest by decreasing expression of cyclinsand CDKsand increases expression of p21and p27. Ailanthone triggers DNA damagecharacterized by activation of the ATM/ATRpathway. Ailanthone induces apoptosiswhich is mitochondrion-mediated and involves the PI3K/AKTsignaling pathway in Huh7 cells. Ailanthone is also a potent inhibitor of both full-length Androgen Receptor(AR-FL) and constitutively active truncated AR splice variants (AR-Vs, AR1-651) with IC50 of 69 nM and 309 nM, respectively. |
