Afatinib Dimaleate, 200mg

Afatinib Dimaleate, 200mg

Afatinib Dimaleate, 10mM/1mL

Afatinib Dimaleate, 10mM/1mL

Afatinib Dimaleate, 1g

5.316,92 RON
SKU
SKM_S7810_1g

Afatinib Dimaleate irreversibly inhibits EGFR/HER2including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Afatinib (BIBW2992) Dimaleate induces autophagy.

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Description

Afatinib Dimaleate irreversibly inhibits EGFR/HER2including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Afatinib (BIBW2992) Dimaleate induces autophagy.