10-Deacetyl-7-xylosyl paclitaxel (10-Deacetyl-7-xylosyltaxol, 7-xylosyl-10-deacetylpaclitaxel), a derivative of paclitaxel and naturally occurring xyloside isolated from Taxus chinensis, causes significant mitotic arrest in PC-3 cells followed by up-regulating expression of pro-apoptotic Bax and Badprotein, as well as down-regulating expression of anti-apoptotic Bcl-2 and Bcl-XL, which leads to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9.
Price | 2.246,00 RON (preturile sunt fara TVA) |
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Description |
10-Deacetyl-7-xylosyl paclitaxel (10-Deacetyl-7-xylosyltaxol, 7-xylosyl-10-deacetylpaclitaxel), a derivative of paclitaxel and naturally occurring xyloside isolated from Taxus chinensis, causes significant mitotic arrest in PC-3 cells followed by up-regulating expression of pro-apoptotic Bax and Badprotein, as well as down-regulating expression of anti-apoptotic Bcl-2 and Bcl-XL, which leads to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9. |