Progenitor cells play a vital role in the replacement and repair of lost or damaged tissue. Most progenitor cells display little or no activity until activated by cytokines, growth factors, or differentiation reagents which not only induce growth and differentiation into a specialized cell type but may mobilize the cell to the site of the damaged tissue.
There is no exact definition of progenitor cells as the concept and understanding of these cells is constantly changing, however, there are several key factors which separate progenitor and precursor cells from stem cells. Unlike a stem cell, which can be multipotent, pluripotent, or totipotent and have a capacity for unlimited self-renewal as an undifferentiated cell, progenitor cells are typically unipotent (precursor cells) or sometimes oligopotent and have a limited capacity for self-renewal as an undifferentiated cell. In some cases, proliferation and differentiation for progenitor cells are inseparable.
Lonza offers a variety of progenitor and precursor cells along with appropriate media for growth and differentiation. Lonza progenitor cells are derived from reliable sources of normal. In addition to cells from non-diseased donors, Lonza also offers preadipocytes from diabetic donors allowing researchers to compare diseased cells to normal primary cells for a better understanding of effects. We offer broad donor variety for each cell type along with extensive donor information for diseased cells such as duration of disease, medications etc. Contact our Scientific Support team for detailed donor information.