2’-O-(2-Methoxyethyl)- oligoribonucleotides or 2’-O-MOE have an analogue chemical structure to RNA excepted that a methoxy-ethyl residue is attached at the 2’-O-position. The chemical group at this position confers to the oligo backbone a highest nuclease resistance and a better binding affi nity compared to the classical RNA molecule making it a useful tool for antisens applications.

Benefits

  • Nuclease resistant
  • High binding affinity
  • Reduced unspecific protein binding
  • Superior half life in tissues
MOE molecular structure
Structure of the 2'-O-MOE (left) vs RNA molecule (right)
(Click on the picture to enlarge it)

 

More info on the Purifications page

More info

2 O-MOE RNA Bases

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