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2 O-MOE RNA Bases
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2’-O-(2-Methoxyethyl)- oligoribonucleotides or 2’-O-MOE have an analogue chemical structure to RNA excepted that a methoxy-ethyl residue is attached at the 2’-O-position. The chemical group at this position confers to the oligo backbone a highest nuclease resistance and a better binding affi nity compared to the classical RNA molecule making it a useful tool for antisens applications.
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