Oligo-2’ O-Methyl (O-Me) nucleotides are resistant (but not totally resistant) to a variety of ribo- and deoxyribonucleases. As well as being stable to normal handling and nuclease resistant, oligo-2’ O-Me-nucleotides form more stable hybrids with complementary RNA strands than equivalent DNA and RNA sequences.

2 O-Me RNA Bases

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