Microbiomics Overview


The advent of Next-Generation sequencing has supercharged our ability to explore both human and environmental microbial ecosystems using targeted sequencing approaches such as 16S rRNA and shotgun sequencing approaches. This has led to an explosion in the field of microbiomics. However, proper standards and quality control measures have lagged behind.  The microbiomics community has expressed a need to standardize methods to improve the reproducibility and quality of the data being generated.  As such, Zymo Research developed the first commercially available Microbiomics Standards for the development, evaluation, calibration, and validation of complex microbiomics workflows encompassing sample collection, sample preparation, and analyses. Zymo Research is also the first supplier to validate every step of the process using Microbial Community Standards to ensure our tools and services are accurate. The ZymoBIOMICS portfolio has been developed as a comprehensive solution for microbiomics and metagenomics from collection to analyses.

Zymo Research provides (1) sample collection tools that can reliably provide a molecular snapshot at the time of collection by stabilizing the nucleic acids at ambient temperature and rendering the sample noninfectious for safe transport; (2) purification methodologies that take into consideration the biases associated with differential lysis efficiency of the organism being processed (e.g. Gram-positive and negative bacteria, fungus, viruses, and associated spores);  (3)  analytical pipelines that reduce bias due to library preparation methods, PCR, and bioinformatics (e.g. GC content, log difference organism abundances, detection limit, and ability to distinguish closely related organisms). 

At Zymo Research, we have made it our goal to eliminate bias across the entire microbiomic workflow. Our new product line, ZymoBIOMICS™, is a complete workflow, from collection to analysis, which offers streamlined collection, purification, and the first microbial community standards.



Microbiomics Technologies


Microbial Standards

Optimize your workflow by identifying & eliminating all bias by using a well-defined and characterized mock microbial community.  (Learn More)

Sample Collection & Preservation

Preserving RNA integrity prior to RNA isolation remains one of the biggest challenges to the success of many RNA applications, and DNA/RNA Shield™ from Zymo Research provides the solution by stabilizing RNA (and DNA) during sample collection, storage, and purification – all while completely inactivating RNases and potentially infectious agents in samples.  (Learn More)

DNA Isolation

Accurately profile a microbial community using the novel lysis system in our ZymoBIOMICS™ DNA Mini Kit, which ensures validated, bias-free DNA purification.  (Learn More) 

RNA Isolation

Accurately profile a microbial community using the novel lysis system in our ZymoBIOMICS™ RNA Mini Kit, which ensures validated, bias-free RNA purification.  (Learn More)

PCR and Quantification Kits

Certified, low-bioburden PCR PreMix with robust amplification enabling the detection of low-copy DNA. Just add water, DNA, primers, and go!  (Learn More)

Microbiomics Services

Comprehensive, validated 16S rRNA and shotgun sequencing services for nonbiased, customizable, publication-quality data.  (Learn More)



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