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OncoTRACE

OncoTRACE   OncoTRACE

 

OncoTRACE este metoda noastra ultrasensibila si individualizata de monitorizare a cancerului dumneavoastra, utilizand biomarcherii prezenti in biopsii lichide (un simplu test sangvin). Aceasta metoda furnizeaza indicii timpurii pentru alegerea unui tratament adecvat.

Descriere

OncoTRACE (RUO) furnizeaza o analiza diferentiata a genomului tumoral si a genomului din ADN-ul normal al pacientului. Analiza consista in efectuarea urmatoarelor trei etape:
* Identificarea biomarcherilor specifici tumorii unui pacient: biomarcherii personalizati pot fi mutatii, rearanjari genetice, etc..
* Validarea biomarcherilor descoperiti si dezvoltarea unui test pentru detectia lor in sange
* Analiza semi-cantitativa in rutina a biomarcherilor personalizati, dintr-o simpla proba de sange.

Acest test este furnizat doar in scop de cercetare, desi utilitatea biomarcherilor din biopsiile lichide a fost validata in diferite articole stiintifice. Descoperirea si validarea biomarcherilor personalizati este o etapa pentru care timpul necesar este greu de estimat de la bun inceput, care variaza de la un pacient la altul. Odata ce testul a fost validat, analiza biomarcherilor dintr-o proba de sange este foarte rapida (mai putin de 5 zile).

Avantaje

Avantajele diagnosticului acestei noi abordari sunt evidente:
* Specificitate extrema: sunt marcheri personalizati, specifici tumorii pacientului
* Foarte rapid (analiza in mai putin de 5 zile, dupa ce biomarcherii personalizati au fost validati)
* Fara interventii invazive masive: e nevoie doar de o simpla proba de sange
* Sensibilitate marita, permitand o detectie timpurie a recidivei (tehnicile de imagerie permit detectia unei tumori doar daca e mai mare de 0,5 cm). De aceea OncoTRACE poate detecta o recidiva a tumorii cu pana la 6 luni inainte de a putea fi detectata prin tehnici de imagerie.
* Informatia este semi-cantitativa, ceea ce inseamna ca diagnoza este mai precisa si putem avea indicii timpurii ale raspunsului la tratamentul ales.

 

 

The First Personalized Liquid Biopsy In The World

The unique personalized non-invasive blood based solution to monitor the evolution of the tumor and the effectiveness of the treatment.

During the development and/or the death of cancer cells, some small fragments of nucleic acids that are not associated with cells or cell fragments are released into the blood. Those DNA fragments are called cell-free circulating DNA (ctDNA).

ctDNA is released by both the primary tumor and metastases, so that its analysis gives a comprehensive and consistent image that reflects the whole genetic landscape of a patient's cancer. ctDNA not only contains the mutations already present in the primary tumor site but also those present in (and perhaps responsible for) metastases.

OncoTRACEOncoTRACE
OncoTRACE

Description

OncoTRACE OncoTRACE is the first & unique solution to monitor the evolution of the disease without any invasive biopsy. It consists in three steps:

  • From the previous sequencing of the tumor of the patient, we identify several variants (from 10 to 15) and we develop a specific assay.
  • From a simple blood sample, we extract the ctDNA and fetch those specific variants by NGS using a very high coverage (median of 15000X). In addition to this specific personalized panel, we also perform a core panel of 28 genes (the one used in our OncoDEEP&TRACE solution ) that have been associated with resistance or sensitivity to several therapies.
  • We make a personalized report taking into account the evolution of the specific variants and the presence of variants that might be associated either with benefits or lack of clinical benefits of some treatments.

 

Advantages

This new and unique approach for cancer monitoring and treatment responses follow-up shows several benefits:

  • Highly specific: we are not fishing for potential surrogates. We target the specific variants from the tumor
  • Through our core panel, we can screen for variants that have been associated with real impact on the treatment
  • Non-invasive procedure (blood sampling) and very fast TAT (7 working days)

 

NB: This solution is only available for any stage III or IV metastatic solid tumor in adults.


Related Solutions

OncoDNA provides multiples solutions for the right cancer approach and cancer treatment

OncoDEEP&TRACE

Combining Solid and Liquid

The Most Complete Molecular Profiling Solution to Deliver the Best Treatment Plan for the patient.

LEARN MORE
OncoSHARE

Online Application

OncoSHARE is the link between the patient, the oncologist, the oncology community and OncoDNA. It allows sample Shipment Kit request, analyses ordering, process follow-up, data analysis and data sharing.

VISIT WEBSITE            REGISTER NOW

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