Reduced representation bisulfite sequencing (RRBS)
DNA methylation studies with RRBS
The latest bisulfite conversion and Illumina sequencing technologies
Single nucleotide resolution through CpG methylation analysis
Reduced representation bisulfite sequencing (RRBS) enables genome-scale DNA methylation analysis in any vertebrate species.
The assay benefits from the practical advantages of bisulfite sequencing while avoiding the cost of whole-genome sequencing.
The Diagenode RRBS service makes this technology widely available and provides high coverage (up to 4 million CpGs in human samples).
Multiplexing prior to bisulfite conversion allows processing of 96 samples per experiment, enabling studies of large cohorts.